Voedingsadvies El MondoResearch Question:
Prospective studies that the association between the magnesium intake through diet or the serum magnesium levels and the risk of getting heart disease, showed conflicting findings see examined. It was therefore carried out this review article.
Lowering a high magnesium intake via diet and a high serum magnesium chances of getting heart disease?
Study Design:
This overview article contained 19 prospective cohort studies (11 studies on magnesium intake via diet, 6 studies on serum magnesium and 2 studies on both) with 532979 participants, of which 19926 participants who got heart disease. The follow-up duration was 7 to 30 years. There was no question of publication bias.
Results and conclusions:
The researchers found that eating 468 mg magnesium per day compared with 223 mg, chances of getting heart disease significantly with 15% [95% CI = 0.78-0.92, there was a low heterogeneity between the studies] reduced. Significant is, there is a link at a 95% reliability.
The researchers found a non-linear relationship between the magnesium intake via diet and reduced risk of getting heart disease. The reduced risk was highest between 150 and 400 mg of magnesium per day.
The researchers found that eating magnesium chances of getting heart disease in men with non-significant 13% [95% CI = 0.74-1.00] reduced and in women significantly with 14% [95% CI = 0.76-0.95] reduced. Non-significant is, there is no link to a 95% reliability.
The researchers found that each increase with 100 mg of magnesium per day the chance of getting heart disease significantly with 9% [95% CI = 0.86-0.96, there was a low heterogeneity between the studies] reduced. Not significant because the risk of 1 in the 95% CI of 0.86-0.96 sat.
The researchers found that the serum magnesium content of 2.07 mEq/L compared with 1.36 mEq/L, chances of getting heart disease significantly with 23% [95% CI = 0.66-0.87, there was a low heterogeneity between the studies] reduced.
The researchers found a linear relationship between the serum magnesium and the reduced risk of getting heart disease. The linear relationship was found between 1.44 and 1.8 mEq/l with a significant, lowered risk of 9% [95% CI = 0.85-0.97] per 0.1 mEq/l.
The researchers concluded that a non-linear relationship existed between the magnesium intake via food (150-400 mg per day) and the reduced risk of heart disease and a linear relationship existed between the serum magnesium (1.44-1.8 mEq/l) and the reduced risk of heart disease.
Original title:
Magnesium and the Risk of Cardiovascular Events: A Meta-Analysis of Prospective Cohort Studies by Qu X, Jin F, [...], Dai K.
Link:
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0057720
Additional information about El Mondo:
Read more about magnesium.