Voedingsadvies El MondoResearch Question:
Epidemiological studies that the association between the blood values of α-tocopherol and γ-tocopherol (the most important bioactive form of vitamin E) and the risk of prostate cancer have explored, let see inconsistent results. In addition, a quantitative assessment of published studies is not available. It was therefore carried out this review article.
Lowers high blood vitamin E-value the chance of getting prostate cancer?
Study Design:
This overview article 9 contained nested case-control studies from different countries with 370000 participants (4004 cases and 6890 controls).
The overall quality of all studies was okay.
The Egger test did not permit a publication bias for α-tocopherol-blood values (p = 0.08) or γ-tocopherol-blood values (p = 0.08) see.
There was significant heterogeneity among the studies with gamma-tocopherol blood values (p = 0.008) but not with alpha tocopherol (α-tocopherol) blood values (p = 0.33).
Results and conclusions:
The researchers found compared to the lowest category, had the highest alpha-tocopherol category a significantly reduced risk of 21% [RR = 0.79, 95% CI = 0.68-0.91] for prostate cancer.
The researchers found compared to the lowest category, had the highest gamma-tocopherol category a non-significant reduced risk of 11% [RR = 0.89, 95% CI = 0.71-1.12] for prostate cancer. Non-significant is, there is no link to a 95% reliability.
The researchers found that every increase in alpha-tocopherol bloedwaarden with 25 mg/L, prostate cancer risk significantly by 21% [RR = 0.79, 95% CI = 0.69-0.91] reduced. Significant is, there is a link at a 95% reliability.
The researchers concluded that only a high alpha-tocopherol bloedwaarde reduced the chance of getting prostate cancer.
Original title:
Blood α-Tocopherol, γ-Tocopherol Levels and Risk of Prostate Cancer: A Meta-Analysis of Prospective Studies by Cui R, Liu ZQ and Xu Q.
Link:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965522/
Additional information about El Mondo:
Find here more studies on vitamin E.