Een hoog plasma homocysteïnegehalte verhoogt waarschijnlijk abdominale aorta aneurysma

Research Question:
Previous studies showed inconsistent findings regarding the link between a high plasma homocysteine levels and abdominal aortic aneurysm (AAA). It was therefore carried out this review article.

Increases the chances of getting a high plasma homocysteine levels of abdominal aortic aneurysm?

Study Design:
This overview article contained 7 case-control studies with 6445 participants, of which 1410 patients with abdominal aortic aneurysm.

There was no question of publication bias.

Results and conclusions:
The researchers found that an increased plasma homocysteine levels the chance of getting an abdominal aortic aneurysm significantly with 229% [95% CI = 1.66-6.51, I2 = 92.9%, p = 0.000] increased.

The researchers found that an increased plasma homocysteine levels the chance of getting an abdominal aortic aneurysm in men non-significant with 136% [95% CI = 0.63-8.82] increased.

The researchers concluded that a high plasma homocysteine levels the chance of getting an abdominal aortic aneurysm probably increased. Probably because this overview article contained only case-control studies and also knew heterogeneity.

Original title:
Homocysteine Level and Risk or Abdominal Aortic Aneurysm: A Meta-Analysis by Cao H, Hu X, [...], Xin S.

Link:
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0085831

Additional information about El Mondo:
Conclusion found in case-control studies is not really reliable because case-control studies very sensitive to errors, which can affect the conclusion. Therefore, the conclusion be confirmed in case-control studies found in cohort studies or in RCTs. Read more study design.

An abdominal aortic aneurysm is a local dilation of the abdominal aorta. An abdominal aortic aneurysm is defined as an aortic diameter of at least one and a half times the diameter measured at the level of the renal arteries. A Dilated abdominal aorta can tear after which the patient can bleed to death within minutes.

  • Risk factors of abdominal aortic aneurysm:
  • Diabetes mellitus (diabetes)
  • Heredity
  • Hypercholesterolemia (high cholesterol)
  • Hypertension (high blood pressure)
  • Age (> 50)
  • Men are more likely than women
  • Smoking