Cancer

Red meat induced colorectal cancer is not modified by NAT2 enzyme activity

Objectives:
Red meat intake has been associated with risk of colorectal cancer, potentially mediated through heterocyclic amines. The metabolic efficiency of N-acetyltransferase 2 (NAT2) required for the metabolic activation of such amines is influenced by genetic variation. The interaction between red meat intake, NAT2 genotype and colorectal cancer has been inconsistently reported. Therefore, this review article has been conducted.

Is there an interaction between red meat intake, NAT2 genotype and colorectal cancer?

High dietary vitamin B9, D, B6 and B2 intake reduces risk of colorectal cancer

Objectives:
Is there an association of intake of different vitamins and multiple-vitamin supplements and the incidence of colorectal cancer?

Study design:
This review article included 47 articles (cohort studies).

There was unacceptable heterogeneity for studies of multiple-vitamin supplements, so findings were inconclusive.

1 mg/day dietary vitamin B2 intake reduces risk of breast cancer

Objectives:
Epidemiological studies assessing the relationship between dietary vitamin B2 and the risk of breast cancer have produced inconsistent results. Therefore, this review article (meta-analysis) has been conducted.

Does dietary vitamin B2 intake reduce breast cancer risk?

Study design:
This review article included 10 epidemiologic studies (cohort or patient-controle studies) comprising totally 12,268 breast cancer patients.

No publication bias was found.

High intake of vegetables and fruit decreases risk of esophageal squamous cell carcinoma

Objectives:
Quantification of the association between the intake of fruit and vegetables and risk of esophageal squamous cell carcinoma (ESCC) is controversial even though several studies have explored this association. Therefore, this review article (meta-analysis) has been conducted.

Does a high intake of vegetables and fruit decrease risk of esophageal squamous cell carcinoma?

Study design:
This review article included a total of 32 observational studies involving 10037 cases of esophageal squamous cell carcinoma.

Daily 2 mg dietary lycopene consumption reduces prostate cancer risk

Objectives:
Prostate cancer (PCa) is the fifth leading cause of cancer-related deaths worldwide. Many epidemiological studies have investigated the association between prostate cancer and lycopene, however, results have been inconsistent. Therefore, this review article (meta-analysis) has been conducted.

Does lycopene reduce prostate cancer risk?

Study design:
This review article included 42 studies including 43,851 cases of prostate cancer reported from 692,012 participants.