Voedingsadvies El MondoResearch Question:
Lowers eating n3-fatty acids the chances of getting breast cancer?
Study Design:
This overview article 26 contained articles that 21 prospective cohort studies (20905 883585 participants, of which people with breast cancer).
11 articles on visinname (13323 with breast cancer patients and 687770 participants), 17 articles on maritime n3-fatty acids intake (16178 with breast cancer patients and 527372 participants) and 12 articles on alpha-linolenic acid intake (with 56811 breast cancer patients and 405592 participants).
There was no question of publication bias.
Results and conclusions:
The researchers found that eating a lot of n3 fatty acids of maritime origin compared to little, the chance of getting breast cancer significantly with 14% [95% CI = 0.78 to 0.94, I2 = 54%] reduced.
The reduced risk remained the same, regardless of whether the n3-fatty acids of maritime origin was measured via the questionnaires [RR = 0.85, 95% CI = 0.89-0.96, I2 = 67%] or via tissue biomarkers (RR = 0.86, 95% = 0.71-1.03, I2 = 8%].
The researchers found that the reduced risk in subgroup analyses between the n3-fatty acids of maritime origin and getting breast cancer was clearer in studies where not corrected was BMI [RR = 0.74, 95% CI = 0.64-0.86, I2 = 0%] than in studies involving corrected was BMI [RR = 0.90, 95% CI = 0.80-1.01, I2 = 63.2%].
The researchers found that every increase of 0.1 grams of n3 fatty acids of maritime origin per day, the chance of getting breast cancer significantly with 5% [95% CI = 0.90-1.00, I2 = 52%] reduced.
The researchers found that every increase of 0.1 grams of alpha-linolenic acid per day, the chance of getting breast cancer is not significantly with 1% [95% CI = 0.98-1.01] reduced.
The researchers found that both eating only EPA [RR = 0.93, 95% CI = 0.85-1.02] as DHA [RR = 0.88, 95% CI = 0.75-1.03] the chance of getting breast cancer are not significantly reduced. Not significant is, there is no link to a 95% reliability.
The researchers found that every increase of 15 grams of fish per day, the chance of getting breast cancer is not reduced or increased [RR = 1.00, 95% CI = 0.97-1.03].
The researchers concluded that eating a lot of n3-fatty acids (at least 0.1 grams per day) of maritime origin (so not plant origin) reduced the chance of getting breast cancer.
Original title:
Intake of fish and marine n-3 polyunsaturated fatty acids and risk of breast cancer: meta-analysis of data from 21 independent prospective cohort studies by Zheng Hu JS, XJ, [...], Li D.
Link:
http://www.bmj.com/content/346/bmj.f3706?view=long&pmid=23814120
Additional information about El Mondo:
N-3 fatty acids common both plant and marine origin. The n-3 fatty acid of plant origin is also known as alpha-linolenic acid. What products contain alpha-linolenic acid, you can look up here.
The n3-fatty acids of maritime origin are EPA and DHA. EPA and DHA are in fish and algae. What fish 100 mg EPA and DHA per day, you can look up here.