Voedingsadvies El MondoResearch Question:
Measurement errors in the food assessment of fruit and vegetables, the associations with the risk of getting breast cancer would weaken and the weak associations observed in epidemiological studies may explain. Carotenoids concentrations in the blood are biomarkers of vegetable and fruit, however no systematic literature review are available on the relationship between the concentrations of carotenoids in the blood and the risk of getting breast cancer. It was therefore carried out this review article.
Lowers a high carotenoid concentration in the blood the chance of getting breast cancer?
Study Design:
This overview article contained relevant studies until 31 August 2011. The random-effects models were used to display the risk.
Results and conclusions:
The researchers found that consumption of 5000 micrograms of beta carotene per day the chance of getting breast cancer significantly with 5% [summary RR = 0.95, 95% CI = 0.91-0.99, n = 10] reduced.
The summary RR for the blood concentration of carotenoids was 0.78 [95% CI = 0.61-0.99, n = 7] per 100 μg/dL. This is to say, people with a blood concentration of 100 μg per dL were significantly less blood carotenoids 22% chance of getting breast cancer. Significant is, there is a link.
The summary RR for the blood concentration of beta-carotene was 0.74 [95% CI = 0.57-0.97, n = 13] per 50 μg/dL.
The summary RR for the blood concentration of Alpha-carotene was 0.82 [95% CI = 0.73-0.92, n = 12] per 10 μg/dL.
The summary RR for the blood concentration of lutein was 0.68 [95% CI = 0.52-0.89, n = 6] per 25 μg/dL.
The researchers concluded that the blood concentrations of carotenoids were more strongly associated with a reduced risk of getting breast cancer than carotenoid intake, obtained through filling in questionnaires.
This review article suggested that the use of certain biomarkers inconsistent and weak associations between dietary intake diet and the risk of getting breast cancer may clarify.
Original title:
Dietary compared with blood concentrations of carotenoids and breast cancer risk: a systematic review and meta-analysis of prospective studies by Aune D, Chan DSM, [...], Norat T.
Link:
http://ajcn.nutrition.org/content/96/2/356.short
Additional information about El Mondo:
Read more about carotenoids in the presentation carotenoids.