Nutritional Advice El Mondo
Objectives:
Are there differences in the laboratory findings between severe patients and non-severe patients with COVID-19?
Study design:
This review article included 35 articles with a total of 5,912 patients with COVID-19.
A total of 5,912 patients (mean age: 54.8 years, including 4,337 non-severe patients (mean age: 48.5) and 1,663 severe patients (mean age: 61 years)).
51.96% of them were male. 2,531 of these patients with underlying disease, including hypertension, diabetes, cardiovascular disease, cerebrovascular disease, chronic obstructive pulmonary disease (COPD), chronic kidney disease and liver disease.
Results and conclusions:
The investigators found that patients with severe COVID-19 possessed higher levels of leukocyte (1.20-fold), neutrophil (1.33-fold), CRP (3.04-fold), PCT (2.00-fold), ESR (1.44-fold), AST (1.40-fold), ALT (1.34-fold), LDH (1.54-fold), CK (1.44-fold), CK-MB (1.39-fold), total bilirubin (1.14-fold), urea (1.28-fold), creatine (1.09-fold), PT (1.03-fold) and D-dimer (2.74-fold), as well as lower levels of lymphocytes (1.44-fold), eosinophil (2.00-fold), monocyte (1.08-fold), hemoglobin (1.53-fold), PLT (1.15-fold), albumin (1.15-fold) and APTT (1.02-fold).
The investigators found lymphocyte subsets and series of inflammatory cytokines were also different in severe cases with the non-severe ones, including lower levels of CD4 T cells (2.10-fold) and CD8 T cells (2.00-fold), higher levels of IL-1β (1.02-fold), IL-6 (1.93-fold) and IL-10 (1.55-fold).
The investigators concluded some certain laboratory inspections could predict the progress of the COVID-19 changes, especially lymphocytes, CRP, PCT, ALT, AST, LDH, D-dimer, CD4 T cells and IL6, which provide valuable signals for preventing the deterioration of the disease.
Original title:
Comparative Analysis of Laboratory Indexes of Severe and Non-Severe Patients Infected With COVID-19 by Bao J, Li C, […], Gu B.
Link:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274996/
Additional information of El Mondo:
Find more information/studies on coronavirus right here.