Nutritional Advice El Mondo
Objectives:
The coronavirus disease 2019 (COVID-19) outbreak is a major threat to human beings. Lung injury has been reported as the major outcome of COVID-19 infection. However, liver damage has also been considered to occur in severe cases. Therefore, this review article has been conducted.
Is liver injury associated with severe coronavirus disease 2019 (COVID-19) infection?
Study design:
This review article included 20 retrospective studies with 3,428 COVID-19 infected patients (severe cases = 1,455 and mild cases = 1,973).
Results and conclusions:
The investigators found higher serum levels of aspartate aminotransferase [weighted mean difference = 8.84 U/L, 95% CI = 5.97 to 11.71, p 0.001], alanine aminotransferase [weighted mean difference = 7.35 U/L, 95% CI = 4.77 to 9.93, p 0.001], total bilirubin [weighted mean difference = 2.30 mmol/L, 95% CI = 1.24 to 3.36, p 0.001] and lower serum levels of albumin [weighted mean difference = -4.24 g/L, 95% CI = -6.20 to -2.28, p 0.001], were associated with a significant increase in the severity of COVID-19 infection.
The investigators concluded the incidence of liver injury, as assessed by serum analysis (aspartate aminotransferase, alanine aminotransferase, total bilirubin and albumin levels), is higher in patients with severe COVID-19 infection.
Original title:
Liver injury is associated with severe Coronavirus disease 2019 (COVID-19) infection: a systematic review and meta-analysis of retrospective studies by Parohan M, Yaghoubi S and Seraj A.
Link:
https://www.ncbi.nlm.nih.gov/pubmed/32386449
Additional information of El Mondo:
Find more information/studies on coronavirus right here.