Pre-existing cardiovascular diseases is associated with worse outcomes among patients with COVID-19

Objectives:
Observational studies have reported an association between underlying cardiovascular diseases (CVD) and worse prognosis in COVID-19 patients, but this still remains unclear. Therefore, this review article has been conducted.

Are cardiovascular diseases associated with worse outcomes among patients with COVID-19?

Study design:
This review article included a total of 18 studies (n = 4,858 patients). 16 studies were from China, while 2 were from the United States.

Results and conclusions:   
The investigators found pre-existing cardiovascular diseases was associated with a significantly increased risk of 214% [OR = 3.14, 95% CI = 2.32 to 4.24, I2 = 0%, p = 0.73] for a severe form of COVID-19.  

The investigators found pre-existing cardiovascular diseases was associated with an elevenfold increased risk of COVID-19 all-cause mortality [OR = 11.08, 95% CI = 2.59 to 47.32, I2 = 55%, p = 0.11].

The investigators found, however, no significant association between previous history of cardiovascular diseases and mortality in severe COVID-19 disease [OR = 1.72, 95% CI = 0.97 to 3.06, I2 = 0%, p = 0.46].

The investigators concluded pre-existing cardiovascular diseases is associated with worse outcomes among patients with COVID-19. Therefore, clinicians and policymakers need to take account of these findings in implementing risk stratification models.

Original title:
Association of Cardiovascular Disease With Coronavirus Disease 2019 (COVID-19) Severity: A Meta-Analysis by Aggarwal G, Cheruiyot I, […], Sanchis-Gomar F.

Link:
https://www.ncbi.nlm.nih.gov/pubmed/32402515

Additional information of El Mondo:
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