COVID-19 infected patients and hospitalization is associated with a case fatality rate of >13%

Afbeelding

Objectives:
An epidemic of Coronavirus Disease 2019 (COVID-19) began in December 2019 in China leading to a Public Health Emergency of International Concern (PHEIC). Clinical, laboratory, and imaging features have been partially characterized in some observational studies. However, no systematic reviews on COVID-19 have been published to date. Therefore, this review article has been conducted.

What is the prevalence of symptoms of COVID-19 infection?

Study design:
This review article included 19 articles for qualitative and quantitative analyses with a total of 656 patients. Additionally, 39 case report articles were included and analyzed separately.

Results and conclusions:
The investigators found for 656 patients, fever [88.7%, 95% CI = 84.5-92.9%], cough [57.6%, 95% CI = 40.8-74.4%] and dyspnea [45.6%, 95% CI = 10.9-80.4%] were the most prevalent manifestations.

The investigators found among 656 patients, 20.3% [95% CI = 10.0-30.6%] required intensive care unit (ICU), 32.8% [95% CI = 13.7-51.8] presented with acute respiratory distress syndrome (ARDS) and 6.2% [95% CI = 3.1-9.3] with shock. Some 13.9% [95% CI = 6.2-21.5%] of hospitalized patients had fatal outcomes (case fatality rate, CFR).

The investigators concluded COVID-19 brings a huge burden to healthcare facilities, especially in patients with comorbidities. Intensive care unit is required for approximately 20% of polymorbid, COVID-19 infected patients and hospitalization is associated with a case fatality rate of >13%. As this virus spreads globally, countries need to urgently prepare human resources, infrastructure and facilities to treat severe COVID-19.

Original title:
Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis by Rodriguez-Morales AJ, Cardona-Ospina JA, […], Sah R.

Link:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102608/

Additional information of El Mondo:
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