Artemether-lumefantrine as a first-line agent in the treatment of uncomplicated Plasmodium falciparum malaria in Ethiopia

Objectives:
As Ethiopia is one of the sub-Saharan countries with a great burden of malaria the effectiveness of first line anti-malarial drugs is the major concern. Therefore, this review article (meta-analysis) has been conducted.

What is the efficacy of artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Ethiopia?

Study design:
This review article included 10 prospective single-arm cohort studies involving 1,179 patients with a mean age of 15.8 years.

At least 28 g/d whole grain intake reduce risk of total, cardiovascular and cancer mortality

Objectives:
Whole grains are rich source of nutrients and have shown beneficial effects on human health. Therefore, this meta-analysis (review article) has been conducted.

Do taking whole grains reduce mortality risk?

Study design:
This review article included 19 cohort studies with in total 1,041,692 participants and 96,710 deaths.

Daily dietary intake of 30g whole grains, 100g fruits, 200g dairy products reduce risk of hypertension

Objectives:
What is the relationship of the intake of whole grains, refined grains, vegetables, fruits, nuts, legumes, eggs, dairy, fish, red meat, processed meat and sugar-sweetened beverages (SSBs) and the risk of hypertension?

Study design:
This review article included 28 prospective cohort studies.

Atrial fibrillation, previous stroke, myocardial infarction, hypertension, diabetes and previous TIA increase risk of post-stroke dementia

Objectives:
Currently, dementia is considered untreatable and there are many factors that cause dementia. However, previous studies were unable to identify the factors that affect directly. Therefore, this meta-analysis (review article) has been conducted.

What are the risk factors for prognostic dementia in stroke patients?

Study design:
This review article included 7 hospital-based cohorts of consecutive patients with stroke and 1 population-based cross-sectional study.

Stroke

  • Strokes are brain attacks. A stroke occurs when the blood supply to part of your brain is interrupted or severely reduced, depriving brain tissue of oxygen and nutrients. Within minutes, brain cells begin to die. When brain cells die during a stroke, abilities controlled by that area of the brain such as memory and muscle control are lost.
  • There are three main types of stroke:
    1. Ischemic stroke. This is the most common type of stroke. A blood clot prevents blood and oxygen from reaching the brain.
    2. Hemorrhagic stroke.

Individual bed net use might reduce risk of malaria

Objectives:
Malaria risk can vary markedly between households in the same village or between villages, but the determinants of this “micro-epidemiological” variation in malaria risk remain poorly understood. Therefore, this review article (meta-analysis) has been conducted.

What are the risk factors for variation in malaria infection between individuals, households, clusters, hotspots or villages in any malaria-endemic setting?

Study design:

Daily 2-4 g carnitine does not reduce cancer-related fatigue

Objectives:
Carnitine deficiency has been implicated as a potential pathway for cancer-related fatigue that could be treated with carnitine supplementation. Therefore, this review article (meta-analysis) has been conducted.

Does carnitine supplementation reduce cancer-related fatigue?

Study design:
This review article included 3 RCTs involving a total of 659 participants.

500 mL/d beetroot juice reduces blood pressure

Objectives:
Beetroot is considered a complementary treatment for hypertension because of its high content of inorganic NO3.

The aim of this meta-analysis (review article) is to clarify several aspects of beetroot juice supplementation on systolic blood pressure (SBP) and diastolic blood pressure (DBP).

Study design:
This review article included 22 RCTs with a total of 47 intervention (n = 650) and 43 control (n = 598) groups.