Artemisinin resistance in South East Asia

Objectives:
Malaria parasites have developed resistance to most of the known antimalarial drugs in clinical practice, with reports of artemisinin resistance emerging in South East Asia (SEA). Therefore, this review article (meta-analysis) has been conducted.

The aim of this review article is find the status of artemisinin resistance and efficacy of different modalities of the current artemisinin-based combination therapies (ACTs).

Study design:
This review article included 82 studies for qualitative and quantitative analysis.

Higher circulating concentration of vitamin C, vitamin E and β-carotene reduce cardiovascular mortality

Objectives:
Do dietary intakes or circulating concentration of major dietary antioxidants, like vitamin C, E and beta-carotene reduce risk of total cardiovascular mortality?

Study design:
This review article included a total of 15 prospective cohort studies and 3 prospective evaluations within interventional studies with 320,548 participants and 16,974 deaths from total cardiovascular mortality.

Results and conclusions:

Dietary low-ratio n-6/n-3 PUFA supplementation improves insulin resistance in diabetic patients

Objectives:
Does a dietary low-ratio n-6/n-3 PUFA supplementation improve risk factors (such as fasting blood glucose, HbA1c) of diabetes?

Study design:
This review article included 11 RCTs.

No significant publication bias was observed for all blood glucose and other related indicators as suggested by Begg's test and Egger's test.

Results and conclusions:
The investigators found no significant effect of dietary low-ratio n-6/n-3 PUFA supplementation on:

Vitamin D improves fasting glucose among patients with chronic kidney disease

Objectives:
Insulin resistance, dyslipidemia and increased systemic inflammation are important risk factors for chronic kidney disease (CKD). Hence, vitamin D administration might be an appropriate approach to decrease the complications of chronic kidney disease. Therefore, this review article has been conducted.

Have vitamin D supplements beneficial effects on people with chronic kidney disease?

One serving of fruits and vegetables per day reduces fractures

Objectives:
Although intake of fruits and vegetables seemed to have a protective effect on bone metabolism, its effect on fractures remains uncertain. Therefore, this review article has been conducted.

Does intake of fruits and vegetables reduce risk of fractures?

Study design:
This review article included 6 cohort studies and 4 RCTs.
6 cohort studies included 225,062 participants (134,365 women and 90,697 men) aged 50 years or older. The participants’ follow-up time ranged from 2.8 years to 20 years.

Hypomagnesemia increases all-cause mortality in end-stage renal disease patients

Objectives:
Previous studies reported that magnesium deficiency was associated with vascular calcifications, atherosclerosis and cardiovascular disease, which might play an independent pathogenic role in chronic kidney disease (CKD) and end-stage renal disease (ESRD) patients. However, the results of these studies were somewhat underpowered and inconclusive. Therefore, this review article has been conducted.

Effectiveness of PCV in preventing of IPD among HIV-infection children is lower than without HIV-infection

Objectives:
HIV-infected children are at a higher risk of invasive pneumococcal disease (IPD) and its mortality, even in the era of antiretroviral therapy. Thus, an effective vaccination strategy would be beneficial. Therefore, this review article (meta-analysis) has been conducted.