Dietary fiber intake reduces endometrial cancer

Objectives:
Does dietary intake of fiber reduce risk of endometrial cancer?

Study design:
This review article included 16 studies, involving 6,563 cases (persons with endometrial cancer).

Results and conclusions:
The investigators found dietary fiber intake significantly reduced risk of endometrial cancer with 14% [RR = 0.86, 95% CI = 0.78 to 0.93].
In stratified analysis, this trend was more pronounced in the case-control studies and in studies conducted in the Americas and Asia.

Middle-aged people with diabetes are at higher risk of developing dementia

Objectives:
Which factors increase risk of dementia?

Study design:
This review article included 34 prospective cohort studies, among which 24 were eligible for meta-analysis. A total of 159,594 non-demented adults were enrolled at baseline before 65 years and 13,540 people were diagnosed with dementia after follow-up.

Results and conclusions:
The investigators found obesity significantly increased risk of dementia with 78% [RR = 1.78, 95% CI = 1.31-2.41].

Soy protein dietary intake reduces type 2 diabetes

Objectives:
Previous findings on the associations of legume and soy intake with the risk of type 2 diabetes are conflicting. Therefore, this review article (meta-analysis) has been conducted.

Does legume or soy dietary intake reduce risk of type 2 diabetes?

Study design:
This review article included 15 unique cohort studies with a total of 565,810 individuals and 32,093 incident cases (persons with type 2 diabetes).

Lead increases ALS

Objectives:
Lead is a known risk factor for amyotrophic lateral sclerosis (ALS). However, the results of studies exploring the relationship between lead exposure and the occurrence of ALS are inconsistent. Therefore, this review article has been conducted.

Does a high lead exposure increase risk of ALS?

High maternal thyroid hormones during pregnancy increase neonatal birth weight

Objectives:
Are growth parameters at birth associated with maternal urinary iodine concentration (UIC) or normal ranges of thyroid hormones during pregnancy?

Study design:
This review article included 11 studies.

The pooled mean birth weight, length and head circumference values and 95% confidence intervals were estimated in newborns born to women with UIC  150 μg/L and UIC ≥150 μg/L during pregnancy.

6 months genistein reduces blood pressure among metabolic syndrome patients

Objectives:
Genistein (4',5,7-trihydroxyisoflavone) is a phytoestrogen with potential health benefits in the prevention of cardiovascular disease. However, the evidence regarding its effects on hypertension has not been conclusive. Therefore, this review article has been conducted.

Do genistein supplements reduce blood pressure?

Study design:
This review article included 4 RCTs (4 treatment arms).