Objectives:
The efficacy of n-3 fatty acids supplementation on the prevention of pregnancy-induced hypertension or preeclampsia remains unclear. Therefore, this meta-analysis (systematic review) has been conducted.

Does n-3 fatty acids supplementation (EPA and/or DHA and/or ALA) decrease risk of pregnancy-induced hypertension and preeclampsia during pregnancy?

Objectives:
There are differences among the outcomes regarding cognitive impairment in heart failure (HF) because the evidence is fragmented and sample size is small. Therefore, this review article has been conducted.

Does heart failure increase risk of dementia?

Study design:
This review article included 12 studies with 2,406,680 heart failure patients.

Begg test, Egger tests and funnel plots showed no significant risks of publication bias.

Objectives:
Data from in vitro and animal studies support the preventive effect of tea (Camellia sinensis) against colorectal cancer. Further, many epidemiologic studies evaluated the association between tea consumption and colorectal cancer risk, but the results were inconsistent. Therefore, this review article has been conducted.

Does tea consumption reduce colorectal cancer risk?

Study design:
This review article included 20 cohort studies with 2,068,137 participants and 21,437 colorectal cancer cases.

Objectives:
Is there a causal relationship between psyllium (a dietary fiber) consumption and improvements of risk factors of diabetes?

Study design:
This review article included 9 RCTs with 395 participants.

Results and conclusions:
The investigators found psyllium consumption significantly reduced triglycerides levels with 19.18 mg/dL [WMD = -19.18 mg/dL, 95% CI = -31.76 to -6.60, I2 = 98%].

Objectives:
Pregnant women represent a category at high risk of severe measles infection, that negatively affects the fetus as well.

Objectives:
Clinical trials examining the cardiovascular protective effects of quercetin in humans have reported conflicting results. Therefore, this review article has been conducted.

Do quercetin supplements reduce plasma lipid levels and blood pressure?

Study design:
This review article included 17 RCTs with a total of 896 participants.

Objectives:
Does high waist circumference increase liver cancer?

Study design:
This review article included  5 prospective cohort studies with 2,547,188 participants.
Participants were aged 46-58 years, with a mean age of 51 years.
The mean follow-up of participants in the studies was 7.8 years.
The mean quality (NOS scores) of the studies included was 7 (ranging from 5 to 9).

Objectives:
Vitamin C as a supplement to treat hypertension has been proposed. However, it remains controversial whether vitamin C can improve blood pressure in patients with primary hypertension. Therefore, this review article has been conducted.

Do vitamin C supplements reduce blood pressure in patients with primary hypertension?

Study design:
This review article included 8 RCTs involving 614 participants.
There was no publication bias.

Objectives:
Plasmodium vivax is a frequent cause of recurring malaria in endemic areas as in its latent stage it resides in liver and is responsible for relapse. Treatment with 8 aminoquinoline Primaquine is given for 14 days, however studies have shown dismal results with adherence to therapy. A new long acting 8 aminoquinoline, Tafenoquine was introduced that showed efficacy and safety almost similar to Primaquine in a single dose regimen, hence giving hopes for improved compliance and help in eradicating malaria.

Objectives:
Is there a causal relationship between intake of pomegranate and decreased risk of getting inflammation in adults?

Study design:
This review article included 16 randomized controlled trials (RCTs) involving 572 subjects.

Results and conclusions:
The investigators found when compared to placebo, that pomegranate supplementation significantly reduced hs-CRP levels [WMD = -6.57 mg/L, 95% CI = -10.04 to -3.10, p = 0.000].