The association between vitamin D deficiency and early spontaneous pregnancy loss (SPL) is unclear. Therefore, this review article (meta-analysis) has been conducted.
Does a vitamin D deficiency increase risk of early spontaneous pregnancy loss?
This review article included 5 studies (case-control and cohort studies), including 10,630 pregnant women.
Results and conclusions:
The investigators found no significant association between a low 25(OH)D level (vitamin D level in blood) and an increased risk of early spontaneous pregnancy loss.
However, the investigators found in subgroup analysis, an extremely low 25(OH)D level (<20 ng/mL) was significantly associated with an 124% increased risk of early spontaneous pregnancy loss in the first trimester [relative risk = 2.24, 95% CI = 1.15-4.37, I2 = 0.0%, p = 0.355].
The investigators concluded that severe vitamin D deficiency (<20 ng/mL) could be detrimental to early embryonic development and increases risk of early spontaneous pregnancy loss.
Meta-analysis of the effect of the maternal vitamin D level on the risk of spontaneous pregnancy loss by Zhang H, Huang Z, [...], Wei Y.