Voedingsadvies El MondoResearch Question:
Previous studies showed inconsistent findings regarding the link between a high plasma homocysteine levels and abdominal aortic aneurysm (AAA). It was therefore carried out this review article.
Increases the chances of getting a high plasma homocysteine levels of abdominal aortic aneurysm?
Study Design:
This overview article contained 7 case-control studies with 6445 participants, of which 1410 patients with abdominal aortic aneurysm.
There was no question of publication bias.
Results and conclusions:
The researchers found that an increased plasma homocysteine levels the chance of getting an abdominal aortic aneurysm significantly with 229% [95% CI = 1.66-6.51, I2 = 92.9%, p = 0.000] increased.
The researchers found that an increased plasma homocysteine levels the chance of getting an abdominal aortic aneurysm in men non-significant with 136% [95% CI = 0.63-8.82] increased.
The researchers concluded that a high plasma homocysteine levels the chance of getting an abdominal aortic aneurysm probably increased. Probably because this overview article contained only case-control studies and also knew heterogeneity.
Original title:
Homocysteine Level and Risk or Abdominal Aortic Aneurysm: A Meta-Analysis by Cao H, Hu X, [...], Xin S.
Link:
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0085831
Additional information about El Mondo:
Conclusion found in case-control studies is not really reliable because case-control studies very sensitive to errors, which can affect the conclusion. Therefore, the conclusion be confirmed in case-control studies found in cohort studies or in RCTs. Read more study design.
An abdominal aortic aneurysm is a local dilation of the abdominal aorta. An abdominal aortic aneurysm is defined as an aortic diameter of at least one and a half times the diameter measured at the level of the renal arteries. A Dilated abdominal aorta can tear after which the patient can bleed to death within minutes.
- Risk factors of abdominal aortic aneurysm:
- Diabetes mellitus (diabetes)
- Heredity
- Hypercholesterolemia (high cholesterol)
- Hypertension (high blood pressure)
- Age (> 50)
- Men are more likely than women
- Smoking