Nutritional Advice El MondoObjectives:
Does magnesium reduce risk of type 2 diabetes?
Study design:
This review article included 35 cohort studies and 26 RCTs (1,168 participants).
Results and conclusions:
The investigators found compared to the lowest magnesium dietary intake, the highest level was associated with a 22% lower risk for type 2 diabetes.
The investigators found the risk for type 2 diabetes was reduced by 6% for each 100mg increment in daily magnesium dietary intake.
The investigators found in 26 RCTs (1,168 participants) that magnesium supplementation significantly reduced:
-the fasting plasma glucose (FPG) level [SMD = -0.32, 95% CI = -0.59 to -0.05];
-2-h oral glucose tolerance test (2-h OGTT) result [SMD = -0.30, 95% CI = -0.58 to -0.02];
-fasting insulin level [SMD = -0.17, 95% CI = -0.30 to -0.04];
-homeostatic model assessment-insulin resistance (HOMA-IR) score [SMD = -0.41, 95% CI = -0.71 to -0.11];
-triglyceride (TG) level;
-systolic blood pressure (SBP) and;
-diastolic blood pressure (DBP).
The investigators found trial sequential analysis (TSA) showed an inverse association, with most benefits of magnesium supplementation on glucose metabolism being stable.
The investigators concluded magnesium dietary intake has an inverse dose-response association with type 2 diabetes incidence and supplementation appears to be advisable in terms of glucose parameters in type 2 diabetes/high-risk individuals.
Original title:
Association of Magnesium Consumption with Type 2 Diabetes and Glucose Metabolism: a Systematic Literature Review and Pooled Study with Trial Sequential Analysis by Zhao B, Deng H, [...], Zhang W.
Link:
https://www.ncbi.nlm.nih.gov/pubmed/31758631
Additional information of El Mondo:
Find more information/studies on diabetes and magnesium consumption right here.