Nutritional Advice El Mondo
Objectives:
Does calcium combined with vitamin D supplementation reduce risk of osteoporosis in postmenopausal women?
Study design:
This review article included 10 RCTs.
Results and conclusions:
The investigators found calcium combined with vitamin D supplementation significantly increased total bone mineral density [SMD = 0.537, 95% CI = 0.227 to 0.847] in postmenopausal women.
The investigators found calcium combined with vitamin D supplementation significantly increased lumbar spine bone mineral density [SMD = 0.233, 95% CI = 0.073 to 0.392, p 0.001] in postmenopausal women.
The investigators found calcium combined with vitamin D supplementation significantly increased arms bone mineral density [SMD = 0.464, 95% CI = 0.186 to 0.741] in postmenopausal women.
The investigators found calcium combined with vitamin D supplementation significantly increased femoral neck bone mineral density [SMD = 0.187, 95% CI = 0.010 to 0.364] in postmenopausal women.
The investigators found calcium combined with vitamin D supplementation significantly reduced risk of hip fracture with 13.6% [RR = 0.864, 95% CI = 0.763 to 0.979] in postmenopausal women.
The investigators found in subgroup analysis that calcium combined with 400 IU/d (10 mcg/d) vitamin D supplementation significantly increased femoral neck bone mineral density [SMD = 0.335, 95% CI = 0.113 to 0.558] in postmenopausal women.
The investigators found in subgroup analysis that dairy products fortified with calcium and vitamin D significantly increased total bone mineral density [SMD = 0.784, 95% CI = 0.322 to 1.247] in postmenopausal women.
The investigators found in subgroup analysis that dairy products fortified with calcium and vitamin D significantly increased lumbar spine bone mineral density [SMD = 0.320, 95% CI = 0.146 to 0.494] in postmenopausal women.
The investigators concluded that dairy products fortified with calcium and vitamin D have a favourable effect on bone mineral density. Furthermore, calcium combined with vitamin D supplementation could prevent osteoporosis hip fracture in postmenopausal women.
Original title:
Effects of combined calcium and vitamin D supplementation on osteoporosis in postmenopausal women: a systematic review and meta-analysis of randomized controlled trials by Liu C, Kuang X […], Li D.
Link:
https://pubmed.ncbi.nlm.nih.gov/33237064/
Additional information of El Mondo:
Find more information/studies on dairy products consumption, calcium and vitamin D right here.