Hepatitis B vaccination does not increase autoimmune diseases risk

Objectives:
Is hepatitis B vaccination in adults causally associated with autoimmune diseases?

Study design:
This review article included 14 controlled studies with documented incidence of autoimmune diseases occurring after hepatitis B vaccinations in adults from January 1990 to March 2017.

Results and conclusions:
The investigators found overall no association between hepatitis B vaccination and the onset of autoimmune diseases [overall odds ratio = 1.06, 95% CI = 0.93-1.21, with non-significant heterogeneity].

Only one study showed a significant excess risk between hepatitis B immunisation and autoimmune disease.

The investigators concluded despite multiple case reports, there is no reliable scientific evidence of autoimmune diseases being caused by hepatitis B vaccinations.

Original title:
Autoimmune diseases after hepatitis B immunization in adults: Literature review and meta-analysis, with reference to 'autoimmune/autoinflammatory syndrome induced by adjuvants' (ASIA) by Elwood JM and Ameratunga R.

Link:
https://www.ncbi.nlm.nih.gov/pubmed/30100071

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