Nutrition and health

Garlic supplementation during 12 weeks reduces fasting blood glucose

Objectives:
Garlic is a common spicy flavouring agent also used for certain therapeutic purposes. Garlic's effects on blood glucose have been the subject of many clinical and animal studies. However, studies reporting hypoglycemic effects of garlic in humans are conflicting. Therefore, this review article (meta-analysis) has been conducted.

Has garlic supplementation lowering effects on glycemic control measurements such as fasting blood glucose (FBG), postprandial glucose (PPG) and glycated haemoglobin (HbA1c)?

Study design:
This review article included a total of 7 RCTs (parallel design) that involved 9 comparisons with 513 subjects. The trials varied in size from 33 to 180 subjects. The study duration varied from 4 to 24 week (median: 12 week). The trials enrolled male and female subjects, both healthy and with diabetes.

Doses of garlic in the treatment group ranged from 600 to 1500 mg/d.

Results and conclusions:
The investigators found pooled analyses showed that garlic supplementation resulted in a statistically significant lowering in fasting blood glucose [SMD = -1.67, 95% CI = -2.80 to -0.55, p = 0.004].

The investigators could not perform a pooled analyse for postprandial glucose (PPG) control and glycosylated haemoglobin (HbA1c) outcomes, because only 1 study included in the meta-analysis reported PPG variables and only 2 studies reported HbA1c variables.

The investigators concluded that garlic supplementation (600 to 1500 mg/d) during 12 weeks results in a lowering in fasting blood glucose. More trials are needed to investigate the effectiveness of garlic on HbA1c and PPG.

Original title:
Garlic intake lowers fasting blood glucose: meta-analysis of randomized controlled trials by Hou LQ, Liu YH and Zhang YY.

Link:
http://apjcn.nhri.org.tw/server/APJCN/24/4/575.pdf

Additional information of El Mondo:
Find more information/studies on diabetes and garlic right here.

Green tea consumption decreases blood pressure among overweight and obese adults

Objectives:
Emerging randomized controlled trials (RCTs) investigating the effect of green tea or green tea extract (GTE) supplementation on blood pressure (BP) among overweight and obese adults reported inconsistent findings. Therefore, this review article has been conducted.

Does tea consumption decrease blood pressure among overweight and obese adults?

Study design:
This review article included 14 RCTs with 971 participants (47% women).

Results and conclusions:
The investigators found green tea or green tea extract supplementation compared with placebo, significantly reduced systolic blood pressure with 1.42 mmHg [95% CI = -2.47 to -0.36, p  =  0.008, I2  =  52%, p for heterogeneity =  0.01 ] among overweight and obese adults.

The investigators found green tea or green tea extract supplementation compared with placebo, significantly reduced diastolic blood pressure with 1.25 mmHg [95% CI = -2.32 to -0.19, p = 0.02, I2 = 74%, p for heterogeneity   0.001] among overweight and obese adults.

The investigators found the quality of evidence across studies was low. Similar results were found in subgroup and sensitivity analyses.

The investigators concluded among overweight and obese adults, green tea or green tea extract supplementation is found to cause a small but significant reduction in blood pressure. However, more high-quality RCTs with large sample sizes are needed to further confirm the efficacy on blood pressure and make strong recommendations for green tea or green tea extract supplementation among the overweight and obese adults.

Original title:
Effect of green tea supplementation on blood pressure among overweight and obese adults: a systematic review and meta-analysis by Li G, Zhang Y, […], Holbrook A.

Link:
http://journals.lww.com/jhypertension/Abstract/2015/02000/Effect_of_green_tea_supplementation_on_blood.6.aspx

Additional information of El Mondo:
Find more information/studies on tea consumption right here.