Nutritional Advice El Mondo
Objectives:
Low vitamin D status is a global public health issue that vitamin D food fortification and biofortification may help to alleviate. Therefore, this review article has been conducted.
Does vitamin D food fortification increase circulating 25(OH)D (vitamin D level in blood) concentrations in populations?
Study design:
This review article included data from 34 publications (2,398 adults: 1,345 intervention (group with vitamin D fortification), 1,053 controls (group without vitamin D fortification) and 1,532 children: 970 intervention, 562 controls).
Results and conclusions:
The investigators found random-effects meta-analysis of all studies combined (mean dose 16.2 μg/d) indicated a pooled treatment effect of 21.2 nmol/L [95% CI = 16.2 to 26.2, I2 > 75%], with a greater effect for studies using cholecalciferol (vitamin D3) than ergocalciferol (vitamin D2).
The investigators found metaregression analyses for all studies combined suggested positive effect differences for baseline circulating 25(OH)D concentrations 50 nmol/L, dose ≥10 μg/d and a negative effect difference when the intervention arm included a calcium dose ≥500 mg/d greater than the control arm.
The investigators found dose-response rates was nonlinear [Wald test for nonlinearity p 0.001].
For all studies combined, a threshold occurred at ∼26 nmol/L for a dose of ∼21 μg/d.
The investigators concluded that vitamin D food fortification (at least 10 μg/d) increases circulating 25(OH)D concentrations in populations.
Original title:
Vitamin D Food Fortification and Biofortification Increases Serum 25-Hydroxyvitamin D Concentrations in Adults and Children: An Updated and Extended Systematic Review and Meta-Analysis of Randomized Controlled Trials by Dunlop E, Kiely ME, […], Black LJ.
Link:
https://pubmed.ncbi.nlm.nih.gov/34113994/
Additional information of El Mondo:
Find more information/studies on RCTs/cohort/significantly/review article, vitamin D, food fortification and malnutrition right here.