Nutritional Advice El Mondo
Objectives:
Despite high 1-dose vaccination coverage, breakthrough varicella infections still occur. Therefore, 2-dose vaccination is recommended to enhance the immune response to the virus. However, the reported incremental vaccine effectiveness (VE) of 2-dose vaccination varies widely among studies. Therefore, this review article has been conducted.
The aim of this review article is to determine the overall effectiveness, immunogenicity and safety of 1 vs. 2-dose varicella vaccination?
Study design:
This review article included studies published during 1995-2017.
Results and conclusions:
The investigators found that the incremental VE/efficacy of 2-dose varicella vaccination was 79% [95% CI = 56%-90%] in RCTs, 63% [95% CI = 36%-79%] in cohort studies and 81% [95% CI = 65%-90%] in case-control studies.
The investigators found regarding immunogenicity, the SMD of geometric mean titer and the pooled relative risk of seroconversion for 2-dose vs. 1-dose varicella vaccine were 562.44 [95% CI = 471.78-653.10] and 1.03 [95% CI = 1.02-1.04], respectively.
The investigators found that children who received second dose varicella vaccination had a significantly increased risk of grade 3 redness of 393% [RR = 4.93, 95% CI = 1.89-12.87] and a significantly increased risk of swelling of any intensity of 34% [RR = 1.34, 95% CI = 1.08-1.66].
The investigators concluded that 2-dose varicella vaccination results in higher levels of immunogenicity and provides superior protection than 1-dose vaccination. Safety profiles show 2-dose vaccination is well tolerated but the incidence of grade 3 redness and of any intensity is significantly higher.
Original title:
Effectiveness, immunogenicity and safety of one vs. two-dose varicella vaccination: a meta-analysis by Yin M, Xu X, […], Ni J.
Link:
https://www.ncbi.nlm.nih.gov/pubmed/29388450
Additional information of El Mondo:
Find more information/studies on food fortification/malnutrition and study design/meta-analysis/significant right here.