Nutritional Advice El Mondo
Objectives:
Inositol (ISL) embraces a family of simple carbohydrates with insulin-sensitizing properties, whose most common isoforms are Myo-inositol (MYO) and D-chiro inositol (DCI). Therefore, this meta-analysis (systematic review) has been conducted.
Does inositol supplementation reduce gestational diabetes (GDM)?
Study design:
This review article included 5 RCTs with a total of 965 participants.
The primary outcome was the preventive effect on gestational diabetes, defined as the rate of gestational diabetes in women without a prior diagnosis of gestational diabetes.
Pooled results were expressed as odds ratio (OR) with a 95% confidence interval (95% CI).
No adverse effects were reported for inositol supplementation.
Results and conclusions:
The investigators found inositol supplementation significantly reduced risk of gestational diabetes with 51% [OR = 0.49, p = 0.01]. However, this reduced risk was only significant in patients receiving 2g inositol twice daily.
The investigators found inositol supplementation significantly reduced risk of preterm delivery with 65% [OR = 0.35, 95% CI = 0.17-0.74, p = 0.006]. However, this reduced risk was only significant in patients receiving 2g inositol twice daily.
The investigators concluded double administration of inositol 2g per day reduces gestational diabetes rate and preterm delivery rate. Therefore, inositol supplementation may represent a novel strategy for gestational diabetes prevention.
Original title:
Inositol for the prevention of gestational diabetes: a systematic review and meta-analysis of randomized controlled trials by Vitagliano A, Saccone G, […], Berghella V.
Link:
https://www.ncbi.nlm.nih.gov/pubmed/30564926
Additional information of El Mondo:
Find more information/studies on inositol and pregnancy right here.