Nutritional Advice El MondoObjectives:
Promising experimental studies suggest that quercetin has potential anti-inflammatory effects. However, the results of current clinical trials on quercetin's effects on the C-reactive protein (CRP), a sensitive inflammatory biomarker, are ambiguous. Therefore, this review article (meta-analysis) has been conducted.
Does quercetin supplementation reduce CRP levels?
Study design:
This review article included 7 RCTs with 10 treatment arms.
Results and conclusions:
The investigators found a significant reduction of circulating CRP levels [WMD = -0.33 mg/L, 95% CI = -0.50 to -0.15, p 0.001] following quercetin supplementation.
The investigators found in subgroup analysis, a significant reducing effect in trials with ≥500 mg/day dosage [WMD = -0.34 mg/L, 95% CI = -0.52 to -0.16, p ≤ 0.001] and in those with CRP 3 mg/L [WMD = -0.34 mg/L, 95% CI = -0.51 to -0.18, p ≤ 0.001].
The investigators found in meta-regression, no association between changes in CRP concentrations, dose of supplementation and CRP baseline values.
The investigators concluded quercetin supplementation reduces circulating C-reactive protein levels; especially at doses above 500 mg/day and in patients with CRP 3 mg/L.
Original title:
Effects of supplementation with quercetin on plasma C-reactive protein concentrations: a systematic review and meta-analysis of randomized controlled trials by Mohammadi-Sartang M, Mazloom Z, […], Firoozi D.
Link:
https://www.ncbi.nlm.nih.gov/pubmed/28537580
Additional information of El Mondo:
Find more information/studies on chronic disease and flavonoids right here. Quercetin is a flavonoid.