Nutritional Advice El Mondo
Objectives:
The aim of this review article is to summarize the evidence for the protective effectiveness of Bacillus Calmette-Guérin (BCG) vaccination against non-tuberculous mycobacterial disease.
Study design:
This review article included 10 studies, including almost 12 million participants.
Results and conclusions:
The investigators found in 3 cohort studies in industrialised countries that the incidence of non-tuberculous mycobacterial lymphadenitis was greatly reduced among BCG-vaccinated children compared to BCG-unvaccinated children, with a risk ratio of 0.04 [95% CI = 0.01 to 0.21].
The investigators found in 2 randomised trials in low-income countries, a significantly reduced risk of 50% [RR = 0.50, 95% CI = 0.37 to 0.69] against Buruli ulcer for the first 12 months following a BCG-vaccination, However, 4 case control studies had conflicting results.
The investigators found no studies had compared different BCG vaccine strains or the effect of revaccination.
The investigators concluded Bacillus Calmette-Guérin (BCG) vaccination protects against non-tuberculous mycobacterial disease. Therefore, the protective effect of BCG vaccination against non-tuberculous mycobacterial should be taken into consideration when deciding on recommendations for discontinuation of universal BCG vaccination programs and in assessing new vaccines designed to replace BCG.
Original title:
Does BCG Vaccination Protect Against Non-Tuberculous Mycobacterial Infection? A Systematic Review and Meta-Analysis by Zimmermann P, Finn A and Curtis N.
Link:
https://www.ncbi.nlm.nih.gov/pubmed/29635431
Additional information of El Mondo:
Find more information/studies on food fortification/malnutrition and study design/meta-analysis/significant right here.