Nutritional Advice El Mondo
Objectives:
Lymphoma etiology remains ill-defined, but immune factors seem to play a major role. The Bacillus Calmette-Guérin (BCG) vaccine, a non-specific stimulator of the cellular immune response, could influence lymphoma risk. Previous studies addressing this issue showed conflicting results. Therefore, this review article has been conducted.
Does BCG vaccination increase lymphoma risk?
Study design:
This review article included 11 studies.
Results and conclusions:
The investigators found BCG vaccination was not associated with Hodgkin's lymphoma [FE summary OR = 1.10, 95% CI = 0.93 to 1.30], but positively associated with non-Hodgkin's lymphoma [RE summary OR = 1.20, 95% CI = 1.01 to 1.43].
The investigators found, however, when restricting to higher quality studies, no association was found between BCG vaccination and either Hodgkin's lymphoma (RE summary OR = 0.97, 95% CI = 0.67 to 1.43] or non-Hodgkin's lymphoma [RE summary OR = 1.15, 95% CI = 0.84 to 1.59].
The investigators concluded, overall, these findings do not support that BCG vaccination is associated with lymphoma risk. Yet, lack of statistical power and relatively high heterogeneity among studies prevent from making definitive conclusions. Future studies investigating this issue are needed, using robust methodology.
Original title:
Association Between Bacillus Calmette-Guerin (BCG) Vaccination and Lymphoma Risk: A Systematic Review and Meta-Analysis by Salmon C, Conus F, […], Rousseau MC.
Link:
https://pubmed.ncbi.nlm.nih.gov/32203929/
Additional information of El Mondo:
Find more information/studies vaccination and maltnutrition right here.