Nutritional Advice El Mondo
Objectives:
Do higher CK-MB concentrations (CK-MB is a biomarker of myocardial injury) increase risk of severity and mortality in COVID-19 patients?
Study design:
This review article included 55 studies with 11,791 COVID-19 patients.
9,596 (48% males, mean age 54 years) with low severity or survivor status and 2,195 (62% males, mean age 66 years) with high severity or non-survivor status during follow up.
Begg's [p = 0.50] and Egger's [p = 0.86] t-tests did not show publication bias.
Accordingly, the trim-and-fill analysis showed that no study was missing or should be added.
Results and conclusions:
The investigators found the pooled results showed that CK-MB concentrations were significantly higher in COVID-19 patients with high disease severity or non-survivor status than COVID-19 patients with low severity or survivor status [SMD = 0.81, 95% CI = 0.61 to 1.01, p 0.001, I2 = 93.4%, p 0.001].
The investigators found sensitivity analysis, performed by sequentially removing each study and re-assessing the pooled estimates, showed that the magnitude and direction of the effect size was not modified [effect size range = 0.77 to 0.84].
The investigators found, meta-regression analysis showed that the SMD was significantly and positively associated with the white blood count, aspartate aminotransferase, myoglobin, troponin, brain natriuretic peptide, lactate dehydrogenase and D-dimer.
The investigators concluded higher CK-MB concentrations are associated with severe disease and mortality in COVID-19 patients. This biomarker of myocardial injury might be useful for risk stratification in this group.
Original title:
Serum CK-MB, COVID-19 severity and mortality: An updated systematic review and meta-analysis with meta-regression by Zinellu A, Sotgia S, [...], Mangoni AA.
Link:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8260505/
Additional information of El Mondo:
Find more information/studies on coronavirus right here.
Creatine kinase-MB (CK-MB) is a form of an enzyme found primarily in heart muscle cells. The CK-MB test is a cardiac marker used to assist diagnoses of an acute myocardial infarction. If you have higher than normal CK-MB enzymes, it may mean you have an inflammation of the heart muscle or are having or recently had a heart attack.
The increase in CK-MB concentration is often evident within 3 to 6 hours following onset of chest pain, reaching peak concentrations within 12 to 24 hours.