Coagulation dysfunction is associated with severity of COVID-19

Objectives:
Is coagulation dysfunction associated with severity of COVID-19?

Study design:
This review article included 34 studies involving 6,492 COVID-19 patients.

Results and conclusions:   
The investigators found meta-analysis showed that COVID-19 patients with severe disease had significantly lower platelet count [WMD = -16.29x109 /L, 95% CI = -25.34 to -7.23] and shorter activated partial thromboplastin time [APTT; WMD = -0.81s, 95% CI = -1.94 to 0.33].  

The investigators found meta-analysis showed that COVID-19 patients with severe disease had significantly higher D-dimer levels [WMD = 0.44μg/mL, 95% CI = 0.29 to 0.58], higher fibrinogen levels [WMD = 0.51g/L, 95% CI = 0.33 to 0.69) and longer prothrombin time [PT; WMD = 0.65s, 95% CI = 0.44 to 0.86].

The investigators found patients who died showed significantly higher D-dimer levels [WMD = 6.58 μg/mL, 95% CI = 3.59 to 9.57], longer PT [WMD = 1.27s, 95% CI = 0.49 to 2.06] and lower platelet count [WMD = -39.73×109 /L, 95% CI = -61.99 to -17.45] than patients who survived.

The investigators concluded coagulation dysfunction is common in severe COVID-19 patients and it is associated with severity of COVID-19.

Original title:
Coagulation dysfunction is associated with severity of COVID-19: a meta-analysis by Zhu J, Pang J, […], Lu J.

Link:
https://pubmed.ncbi.nlm.nih.gov/32706396/

Additional information of El Mondo:
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