Nutritional Advice El Mondo
Objectives:
Does chloroquine or hydroxychloroquine with or without azithromycin decreased the mortality of COVID-19 compared to standard of care?
Study design:
This review article included 29 articles (3 were randomized controlled trials (RCTs), 1 was a non-randomized trial and 25 were observational studies, including 10 with a critical risk of bias and 15 with a serious or moderate risk of bias) with a total of 15,190 COVID-19 patients in the hydroxychloroquine group, 8,081 COVID-19 patients for the hydroxychloroquine with azithromycin group and 14,060 COVID-19 patients in the standard of care group with 3,152 deaths, 1,063 deaths and 2,857 deaths, respectively.
Mean (± SD) age of participants was 62.1 ± 8.5 years.
Results and conclusions:
The investigators found hydroxychloroquine was not significantly associated with mortality [pooled relative risk = 0.83, 95% CI = 0.65 to 1.06, n = 17 studies] for all studies and relative risk = 1.09, 95% CI = 0.97 to 1.24, n = 3 studies] for RCTs.
The investigators found hydroxychloroquine with azithromycin was associated with a significantly increased risk of 27% for mortality [RR = 1.27, 95% CI = 1.04 to 1.54, n = 7 studies].
The investigators found similar results with a Bayesian meta-analysis.
The investigators concluded hydroxychloroquine alone is not associated with reduced mortality in hospitalized COVID-19 patients but the combination of hydroxychloroquine and azithromycin increase mortality.
Original title:
Effect of hydroxychloroquine with or without azithromycin on the mortality of COVID-19 patients: a systematic review and meta-analysis by Fiolet T, Guihur A, […], Mahamat-Saleh Y.
Link:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7449662/
Additional information of El Mondo:
Find more information/studies on coronavirus right here.