Concomitant administration of other vaccines along with HPV vaccine does not interfere with immune response to HPV vaccine

Objectives:
Adolescents and young adults are at a high risk of developing human papillomavirus (HPV) infections, which can be prevented with the use of vaccines. Moreover, a combined immunization strategy for administration of HPV vaccines with other routine vaccines may lead to better compliance.

The goal of this review article is to evaluate immunogenicity and safety in the case of concomitantly administered HPV vaccine in individuals aged 9-25 years.

Study design:
This review article included a total of 13 studies (11,657 participants).

Results and conclusions:
The investigators found between the concomitant and nonconcomitant administration groups, the seroconversion rate for the specific antibodies against all HPV types (type 16-, 18-, 6-, 11-, 31-, 33-, 45-, 52- and 58) were the same [pooled RR = 1.00, 95% CI = 1.00-1.00] for the bivalent HPV (2vHPV) vaccine.

The investigators found between the concomitant and nonconcomitant administration groups, the risks of local adverse events showed no significant difference [pooled RR = 1.00, 95% CI = 0.97-1.04] and the risks of systemic adverse events were almost similar [pooled RR = 1.10, 95% CI = 1.03-1.18] for the non-bivalent HPV (4vHPV and 9vHPV) vaccines.

The investigators found between the concomitant and nonconcomitant administration groups, the risks of local adverse events were slightly higher in the concomitant administration groups [pooled RR = 1.31, 95% CI = 1.17-1.47] and the risks of systemic adverse events were higher in the concomitant administration groups [pooled RR = 2.09, 95% CI = 1.69-2.59].

The investigators concluded that the concomitant administration of other vaccines along with HPV vaccine is acceptable and there is no interference with the immune response to HPV vaccine. Concomitant vaccine administration has the potential to minimize the number of vaccination visits, leading to increased compliance, hence more effective disease prevention.

Original title:
Immunogenicity and safety of human papillomavirus vaccine coadministered with other vaccines in individuals aged 9-25 years: A systematic review and meta-analysis by Li Y, Zhu P, […], Li L.

Link:
https://www.ncbi.nlm.nih.gov/pubmed/31831220

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