Nutritional Advice El MondoObjectives:
Does a treatment with convalescent plasma decrease all-cause mortality risk in COVID-19 patients?
Study design:
This review article included 4 peer-reviewed RCTs with a total of 1,060 COVID-19 patients and 6 other publicly available RCTs with 10,722 COVID-19 patients.
The mean age of patients was younger than 70 years and they were typically male (≤80%).
The certainty of the evidence was low to moderate for all-cause mortality and low for other outcomes.
Results and conclusions:
The investigators found in the 4 peer-reviewed RCTs, a non-significantly reduced risk of 7% for all-cause mortality in the group with convalescent plasma [summary risks ratio = 0.93, 95% CI = 0.63 to 1.38].
The absolute risk difference was -1.21% [95% CI = -5.29% to 2.88%] and there was low certainty of the evidence due to imprecision.
The investigators found across all 10 RCTs, the summary RR was 1.02 [95% CI = 0.92 to 1.12) and there was moderate certainty of the evidence due to inclusion of unpublished data.
The investigators found among the peer-reviewed RCTs, the summary hazard ratio was 1.17 [95% CI = 0.07 to 20.34] for length of hospital stay, the summary RR was 0.76 [95% CI = 0.20 to 2.87] for mechanical ventilation use (the absolute risk difference for mechanical ventilation use was -2.56% [95% CI = -13.16% to 8.05%]) and there was low certainty of the evidence due to imprecision for both outcomes.
The investigators found limited data on clinical improvement, clinical deterioration and serious adverse events showed no significant differences.
The investigators concluded that treatment with convalescent plasma compared with placebo or standard of care is not significantly associated with a decrease in all-cause mortality or with any benefit for other clinical outcomes. The certainty of the evidence was low to moderate for all-cause mortality and low for other outcomes.
Original title:
Association of Convalescent Plasma Treatment With Clinical Outcomes in Patients With COVID-19: A Systematic Review and Meta-analysis by Janiaud P, Axfors C, […], Hemkens LG.
Link:
https://jamanetwork.com/journals/jama/fullarticle/2777060
Additional information of El Mondo:
Find more information/studies on corona virus right here.