COVID-19 patients from North American, European and Middle East countries suffer more severe liver, kidney and heart damage

Objectives:
Are there differences in clinical manifestations between COVID-19 patients from the East (East and South-East Asian countries including China, South Korea and Thailand) and the West (North American, European and Middle East countries, including the United States, Italy, France and Iran)?

Study design:
This review article included 57 studies, describing 19,353 patients. Of these, 45 studies with 8,416 patients were from the East, while 12 studies with 10,937 patients were from the West.

Results and conclusions:                
The investigators found that results indicated that the incidences of cough, headache, dizziness, nasal congestion and digestive symptoms in COVID-19 patients from the East were lower than those in the West.

The investigators found the laboratory data showed that there were no significant differences in the levels of lymphocytes, leukocytes, C-reactive protein and platelet counts between the two groups.

The investigators found, in addition, results also showed that the incidence of cardiac and kidney injury, as well as increased levels of creatinine, alanine transaminase and aspartate transaminase, were significantly higher in patients from the West than from the East.

The investigators concluded that there are differences in the clinical manifestations of COVID-19 in patients from the East and the West. COVID-19 patients from the West (North American, European and Middle East countries, including the United States, Italy, France and Iran) appear to suffer more severe liver, kidney and heart damage due to COVID-19 infection.

Original title:
East-West differences in clinical manifestations of COVID-19 patients: A systematic literature review and meta-analysis by Liu X, Li X, [...], Zhang H.

Link:
https://pubmed.ncbi.nlm.nih.gov/33325107/

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