Nutritional Advice El Mondo
Objectives:
Epidemiological studies focusing on the association between folate and breast cancer risk reported inconsistent findings. Therefore, this review article has been conducted.
Does dietary folate intake reduce breast cancer risk?
Study design:
This review article included a total of 23 prospective cohort studies involving 41,516 cases (=women with breast cancer) among 1,171,048 individuals.
Results and conclusions:
The investigators found dietary folate intake significantly reduced risk of oestrogen-receptor-negative breast cancer with 12% [pooled risk ratio = 0.88, 95% CI = 0.78-1.00].
The investigators found dietary folate intake significantly reduced risk of oestrogen-receptor-negative/progesterone-receptor-negative breast cancer with 18% [pooled risk ratio = 0.82, 95% CI = 0.68-0.97].
The investigators found an increment of dietary folate intake of 100 μg per day was associated with a deceased risk of oestrogen-receptor-negative breast cancer with 6% [RR = 0.94, 95% CI = 0.88-0.99].
The investigators found an increment of dietary folate intake of 100 μg per day was associated with a deceased risk of oestrogen-receptor-negative/progesterone-receptor-negative breast cancer with 10% [RR = 0.90, 95% CI = 0.85-0.97].
The investigators found high dietary folate intake significantly reduced breast cancer risk in premenopausal women with 6% [RR = 0.94, 95% CI = 0.88-1.00].
The investigators found high dietary folate intake significantly reduced breast cancer risk in women with moderate or high levels of alcohol consumption with 18% [RR = 0.82, 95% CI = 0.72-0.94].
The investigators concluded that at least 100 μg per day dietary folate intake, reduce both oestrogen-receptor-negative and oestrogen-receptor-negative/progesterone-receptor-negative breast cancer, particularly among premenopausal women and women with moderate or high levels of alcohol consumption.
Original title:
Folate intake and the risk of breast cancer: an up-to-date meta-analysis of prospective studies by Zeng J, Wang K, [...], Chang H.
Link:
https://www.ncbi.nlm.nih.gov/pubmed/30647438
Additional information of El Mondo:
Find more information/studies on folate consumption, review article/significantly and breast cancer right here.