Daily 40g soy consumption for <12 weeks increase IGF-1 level

Objectives:
A low insulin-like growth factor 1 (IGF-1) level is known to be associated with many disorders. Several studies have shown that soy consumption may influence IGF-1, but the findings remain inconclusive. Therefore, this review article (meta-analysis) has been conducted.

Does soy consumption increase insulin-like growth factor 1 (IGF-1) level?

Study design:
This review article included 8 clinical trials.

Results and conclusions:
The investigators found, overall, a significant increment in plasma IGF-1 was observed following soy intervention [WMD = 13.5 ng/mL, 95% CI = 5.2 to 21.8, I2 = 97%].

The investigators found, subgroup analyses demonstrated a significantly greater increase in IGF-1, when soy was administered at a dosage of ≤40 g/day [WMD = 11.7 ng/mL, 95% CI = 10.9 to 12.6, I2 = 98%] and when the intervention duration was 12 weeks [WMD = 26.6 ng/mL, 95% CI = 9.1 to 44.1, I2 = 0.0%].

The investigators found, in addition, soy intervention resulted in a greater increase in IGF-1 among non-healthy subjects [WMD = 36 ng/mL, 95% CI = 32.7 to 39.4, I2 = 84%] than healthy subjects [WMD = 9.8 ng/mL, 95% CI = 8.9 to 10.7, I2 = 90%].

The investigators concluded ≤40 grams of soy consumption per day during 12 weeks increase the IGF-1 level.

Original title:
The Effect of Soy Intervention on Insulin-Like Growth Factor 1 Levels: A Meta-Analysis of Clinical Trials by Jiawei Zeng J, Feng Y, […], Chen X.

Link:
https://pubmed.ncbi.nlm.nih.gov/32072706/

Additional information of El Mondo:
Find more information/studies on subgroup analysis/significant and soja consumption right here.