Nutritional Advice El Mondo
Objectives:
Is pre-existing diabetes associated with greater risk of severe/critical illness and in-hospital mortality in patients admitted to hospital with COVID-19?
Study design:
This review article included a total of 83 eligible studies with 78,874 hospitalized adult patients with laboratory-confirmed COVID-19 (52.1% men; median age 54 years [inter-quartile range: 49-62 years]).
Funnel plots and Egger's tests did not reveal any significant publication bias.
Results and conclusions:
The investigators found pooled prevalence of established diabetes was 14.34% [95% CI = 12.62 to 16.06%].
The investigators found, however, the prevalence of diabetes was higher in non-Asian vs. Asian countries 23.34% [95% CI = 16.40 to 30.28] vs. 11.06% [95% CI = 9.73 to 12.39], and in patients aged ≥60 years vs. those aged 60 years 23.30% [95% CI = 19.65 to 26.94] vs. 8.79% [95% CI = 7.56 to 10.02].
The investigators found pre-existing diabetes was associated with an approximate twofold higher risk of having severe/critical COVID-19 illness [n = 22 studies; random-effects odds ratio = 2.10, 95% CI = 1.71 to 2.57, I2 = 41.5%] and ~threefold increased risk of in-hospital mortality [n = 15 studies; random-effects odds ratio = 2.68, 95% CI = 2.09 to 3.44, I2 = 46.7%].
The investigators concluded pre-existing diabetes (in most cases type 2 diabetes mellitus) is associated with a two to three times greater risk of severe/critical illness and in-hospital mortality associated with COVID-19. These findings highlight the urgent need of a multidisciplinary team-based approach to the management of this patient population.
Original title:
Diabetes as a Risk Factor for Greater COVID-19 Severity and In-Hospital Death: A Meta-Analysis of Observational Studies by Mantovani A, Byrne CD, […], Targher G.
Link:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7258796/
Additional information of El Mondo:
Find more information/studies on coronavirus and diabetes right here.