Nutritional Advice El Mondo
Objectives:
Previous studies have demonstrated some associations between dietary vitamin A intake and ovarian cancer risk with an inconsistent relationship. Therefore, this review article (meta-analysis) has been conducted.
Does higher dietary intake of vitamin A reduce ovarian cancer risk?
Study design:
This review article included 10 case-control studies and 5 cohort studies, involving 4,882 cases (persons with ovarian cancer) among 443,179 participants.
There was no publication bias.
Results and conclusions:
The investigators found higher dietary vitamin A intake significantly reduced ovarian cancer risk with 18.4% [RR = 0.816, 95% CI = 0.723 to 0.920, I2 = 48.4%, p for heterogeneity = 0.019].
Sensitivity analysis showed that no single study had a potential impact on the pooled RR.
The investigators found higher dietary vitamin A intake significantly reduced ovarian cancer risk with 23.1% [RR = 0.769, 95% CI = 0.655 to 0.902] in case-controle studies.
However, this reduced risk was not significant in cohort studies.
The investigators found higher dietary vitamin A intake significantly reduced ovarian cancer risk with 17.5% [RR = 0.825, 95% CI = 0.720 to 0.946] in North American populations.
The investigators concluded that higher dietary intake of vitamin A reduces ovarian cancer risk, especially among North Americans. As some limitations existed in this analysis, large scale studies with detailed amount of dietary vitamin A intake are needed to verify the results.
Original title:
Dietary vitamin A intake and the risk of ovarian cancer: A meta-analysis by Wang Q and He C.
Link:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138903/
Additional information of El Mondo:
Find more information/studies on vitamin A intake and cancer right here.