Nutritional Advice El Mondo
Objectives:
There are differences among the outcomes regarding cognitive impairment in heart failure (HF) because the evidence is fragmented and sample size is small. Therefore, this review article has been conducted.
Does heart failure increase risk of dementia?
Study design:
This review article included 12 studies with 2,406,680 heart failure patients.
Begg test, Egger tests and funnel plots showed no significant risks of publication bias.
Results and conclusions:
The investigators found heart failure significantly increased risk of all-cause dementia with 28% [OR/RR = 1.28, 95% CI = 1.15 to 1.43, I2 = 70.0%, p 0.001].
Sensitivity analysis showed no changes in the direction of effect when any one study was excluded for the studies on associations between heart failure and all-cause dementia.
The investigators found no significant association between heart failure and risk of Alzheimer's disease [OR/RR = 1.38, 95% CI = 0.90 to 2.13, I 2 = 74.8%, p = 0.008].
Sensitivity analysis showed no changes in the direction of effect when any one study was excluded for the studies on associations between heart failure and Alzheimer's disease.
The investigators concluded heart failure increases risk of all-cause dementia. In addition, large scale prospective studies are essential to explore the associations between heart failure and risk of Alzheimer's disease.
Original title:
Associations between heart failure and risk of dementia: A PRISMA-compliant meta-analysis by Li J, Wu Y, [...], Nie J.
Link:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004760/
Additional information of El Mondo:
Find more information/studies on heart failure and dementia right here.