Nutritional Advice El Mondo
Objectives:
Coronavirus disease 2019 (COVID-19) is a global pandemic impacting 213 countries/territories and more than 5,934,936 patients worldwide. Cardiac injury has been reported to occur in severe and death cases. Therefore, this review article has been conducted.
Is cardiac injury, as assessed by serum analysis (lactate dehydrogenase, cardiac troponin I, creatine kinase (-MB) and myoglobin), associated with severe outcome and death from COVID-19 infection?
Study design:
This review article included 22 studies with 3,684 COVID-19 infected patients (severe cases = 1,095 and death cases = 365).
All studies were conducted in China. 20 studies used retrospective design and 2 studies used prospective design.
The sample size of studies ranged from 10 to 645 patients (mean age in severe patients: 60.95 years, mean age in non-severe patients: 46.95 years).
Based on the results of Egger’s test, no evidence of publication bias was found for lactate dehydrogenase (p = 0.454), creatine kinase-MB (p = 0.367), creatine kinase (p = 0.220), cardiac troponin I (p = 0.961) and myoglobin (p = 0.748).
Results and conclusions:
The investigators found higher serum levels of lactate dehydrogenase [WMD = 108.86 U/L, 95% CI = 75.93 to 141.79, p 0.001] and creatine kinase-MB [WMD = 2.60 U/L, 95% CI = 1.32 to 3.88, p 0.001] were associated with a significant increase in the severity of COVID-19 infection.
Sensitivity analysis indicated that overall estimates did not depend on a single publication.
The investigators found, furthermore, higher serum levels of lactate dehydrogenase [WMD = 213.44 U/L, 95% CI = 129.97 to 296.92, p 0.001], cardiac troponin I [WMD = 26.35 pg/mL, 95% CI = 14.54 to 38.15, p 0.00]), creatine kinase [WMD = 48.10 U/L, 95% CI = 0.27 to 95.94, p = 0.049] and myoglobin [WMD = 159.77 ng/mL, 95% CI = 99.54 to 220.01, p 0.001] were associated with a significant increase in the mortality of COVID-19 infection.
Sensitivity analysis indicated that overall estimates did not depend on a single publication.
The investigators concluded cardiac (heart) injury, as assessed by serum analysis (lactate dehydrogenase, cardiac troponin I, creatine kinase (-MB) and myoglobin), is associated with severe outcome and death from COVID-19 infection. With the fast-moving development of COVID-19 across the globe and with better understanding of the mechanisms of cardiac involvement in patients with COVID-19 infection, cardiac biomarkers can be utilized as an indicator of improving response due to cardioprotective intervention or as a metric of a worsening clinical scenario.
Original title:
Cardiac Injury Is Associated With Severe Outcome and Death in Patients With Coronavirus Disease 2019 (COVID-19) Infection: A Systematic Review and Meta-Analysis of Observational Studies by Parohan M, Yaghoubi S and Seraji A.
Link:
https://journals.sagepub.com/doi/full/10.1177/2048872620937165
Additional information of El Mondo:
Find more information/studies on coronavirus right here.