Hepatitis B virus (HBV) vaccination may not increase multiple sclerosis risk

Objectives:
Does Hepatitis B virus (HBV) vaccination increase multiple sclerosis risk?

Study design:
This review article included 7 articles.
Funnel plot showed the presence of publication bias.

Results and conclusions:
The investigators found no statistically significant association was observed for Hepatitis B virus (HBV) vaccination and multiple sclerosis risk [pooled OR = 1.19, 95% CI = 0.96-1.49 and for pooled adjusted OR = 0.965, 95% CI = 0.886-1.051].

The investigators found meta regression showed that year of publication was negatively [β: -0.019, p 0.001] and NOS score and publishing in Europe are positively associated with OR value.

The investigators concluded Hepatitis B vaccination may not be associated with an increased risk of developing multiple sclerosis. May not be associated because there was publication bias.

Original title:
HBV vaccine and risk of developing multiple sclerosis: a systematic review and meta-analysis by Sestili C, Grazina I and La Torre G.

Link:
https://www.ncbi.nlm.nih.gov/pubmed/30260264

Additional information of El Mondo:
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