Nutritional Advice El MondoObjectives:
Is there an association of intake of different vitamins and multiple-vitamin supplements and the incidence of colorectal cancer?
Study design:
This review article included 47 articles (cohort studies).
There was unacceptable heterogeneity for studies of multiple-vitamin supplements, so findings were inconclusive.
Results and conclusions:
The investigators found a significant reduced risk of 12% [multivariable-adjusted RR = 0.88, 95% CI = 0.81-0.95] for colorectal cancer when comparing the highest versus lowest dietary vitamin B9 (folate) intake. Significant means that there is an association with a 95% confidence.
The investigators found a significant reduced risk of 13% [multivariable-adjusted RR = 0.87, 95% CI = 0.77-0.99] for colorectal cancer when comparing the highest versus lowest dietary vitamin D intake. Significant because RR of 1 was not found in the 95% CI of 0.77 to 0.99. RR of 1 means no risk/association.
The investigators found a significant reduced risk of 12% [multivariable-adjusted RR = 0.88, 95% CI = 0.79-0.99] for colorectal cancer when comparing the highest versus lowest dietary vitamin B6 intake.
The investigators found a significant reduced risk of 14% [multivariable-adjusted RR = 0.86, 95% CI = 0.76-0.97] for colorectal cancer when comparing the highest versus lowest dietary vitamin B2 intake.
The investigators found, however, no association between both dietary vitamine A, C, E, B3 and B12 and the risk of colorectal cancer.
The investigators concluded high dietary vitamin B9 (folate), D, B6 and B2 intake reduces risk of colorectal cancer, but further study is needed.
Original title:
Vitamin and multiple-vitamin supplement intake and incidence of colorectal cancer: a meta-analysis of cohort studies by Liu Y, Yu Q, […], Li K.
Link:
https://www.ncbi.nlm.nih.gov/pubmed/25491145
Additional information of El Mondo:
Find more studies/information on vitamines and colorectal cancer right here.