Nutritional Advice El Mondo
Objectives:
Anemia is one of the major complications in predialysis patients with chronic kidney disease (CKD). A clearer cognition of the prognostic impact of hemoglobin (Hb) or hematocrit (Hct) target on the outcomes of predialysis patients with CKD is significant. Therefore, this review article (meta-analysis) has been conducted.
Does higher hemoglobin levels decrease transfusion risk in predialysis patients with CKD?
Study design:
This review article included 13 RCTs involving 7,606 patients.
Results and conclusions:
The investigators found compared to lower hemoglobin levels, predialysis patients with chronic kidney disease with higher hemoglobin levels had a significantly lower risk of 49% for transfusion [risk ratio = 0.59, 95% CI = 0.52 to 0.67, p 0.00001].
The investigators found, however, no significant difference in all-cause mortality [RR = 1.10, 95% CI = 0.98 to 1.23, p = 0.11], stroke [RR = 1.32, 95% CI = 0.82 to 2.10, p = 0.25] and treatment of renal replacement including hemodialysis, peritoneal dialysis and renal transplant [RR = 1.08, 95% CI = 0.95 to 1.22, p = 0.23] between the higher hemoglobin group and the lower one.
The investigators concluded higher hemoglobin levels when treating predialysis patients with chronic kidney disease decrease the risk of transfusion without increasing the risk of death, stroke and treatment of renal replacement.
Original title:
Therapeutic targets for the anemia of predialysis chronic kidney disease: a meta-analysis of randomized, controlled trials by Liu H, Ye Y, […], Liu X.
Link:
https://www.ncbi.nlm.nih.gov/pubmed/30755495
Additional information of El Mondo:
Find here more information/studies about chronic diseases.