Nutritional Advice El Mondo
Objectives:
There is mounting evidence related to the association between obesity and severity of COVID-19. However, the direct relationship of the increase in the severe COVID-19 risk factors, with an increase in body mass index (BMI), has not yet been evaluated. Therefore, this review article has been conducted.
Is there a dose-response relationship between body mass index (BMI) and poor outcome in patients with COVID-19?
Study design:
This review article included 12 studies with a total of 34,390 COVID-19 patients.
Results and conclusions:
The investigators found meta-analysis demonstrated that obesity was associated with composite poor outcome [OR = 1.73, 95% CI = 1.40 to 2.14, p 0.001, I2 = 55.6%], mortality [OR = 1.55, 95% CI = 1.16 to 2.06, p = 0.003, I2 = 74.4%] and severity [OR = 1.90, 95% CI = 1.45 to 2.48, p 0.001, I2 = 5.2%] in patients with COVID-19.
The investigators found pooled analysis of highest BMI versus reference BMI indicate that a higher BMI in the patients was associated with composite poor outcome [aOR = 3.02, 95% CI = 1.82 to 5.00, p 0.001, I2 = 59.8%], mortality [aOR = 2.85, 95% CI = 1.17 to 6.92, p = 0.002, I2 = 79.7%] and severity [aOR = 3.08, 95% CI = 1.78 to 5.33, p 0.001, I2 = 11.7%].
The investigators found the dose-response meta-analysis showed an increased risk of composite poor outcome by aOR of 1.052, 95% CI = 1.028 to 1.077, p 0.001 for every 5 kg/m2 increase in BMI [p non-linearity 0.001]. The curve became steeper with increasing BMI.
The investigators concluded that increased BMI is associated with increased poor outcome in patients with COVID-19.
Original title:
Body Mass Index and Outcome in Patients with COVID-19: A Dose-Response Meta-Analysis by Pranata R, Lim MA, […], Meyer M.
Link:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7388778/
Additional information of El Mondo:
Find more information/studies on coronavirus right here.