Nutritional Advice El Mondo
Objectives:
Do low folate levels and vitamin B12 levels increase risk of depression among the aged people?
Study design:
This review article included both gender data of 11 folate-related (7,949 individuals) and 9 B12-related studies (6,308 individuals) and gender-specific data of 4 folate-related (3,409 individuals) and 3 B12-related studies (1,934 individuals).
Results and conclusions:
The investigators found low folate levels significantly increased risk of depression among the aged people with 23% [OR =1.23, 95% CI =1.07-1.43].
The investigators found low vitamin B12 levels significantly increased risk of depression among the aged people with 20% [OR =1.20, 95% CI =1.02-1.42].
The investigators found in subgroup analysis low vitamin B12 levels significantly increased risk of depression among the aged women with 33% [OR =1.33, 95% CI =1.02-1.74].
The investigators concluded both low folate levels and low vitamin B12 levels increase risk of depression among the aged people.
Original title:
Folate and B12 serum levels in association with depression in the aged: a systematic review and meta-analysis by Petridou ET, Kousoulis AA, [...], Stefanadis C.
Link:
https://www.ncbi.nlm.nih.gov/pubmed/26055921
Additional information of El Mondo:
Find more information/studies on vitamin B12, folate and elderly.