Nutritional Advice El MondoObjectives:
Some studies have reported the association between maternal serum zinc (Zn) levels and pre-eclampsia. However, many studies have reported controversial results. Therefore, this review article has been conducted.
Does a low maternal serum zinc level increase risk of pre-eclampsia in African women?
Study design:
This review article included 12 observational studies.
Results and conclusions:
The investigators found the mean values of serum zinc level were significantly lower in pre-eclamptic women as compared with normotensive pregnant women [zinc = 59.40 ± 22.80 μg/dL and 80.24 ± 16.04 μg/dL], respectively.
The investigators found the pooled SMD of zinc was significantly reduced in pre-eclamptic women as compared with normotensive pregnant women with the SMD of -1.45 [95% CI -2.26 to -0.65].
The investigators concluded that the maternal serum zinc level is lower in pre-eclamptic women than normotensive pregnant women. This suggests that zinc could be involved in the etio-pathogenesis of pre-eclampsia. However, the specific functions of zinc in pre-eclampsia pathogenesis should be proved in large-scale clinical trial studies.
Original title:
Maternal Serum Zinc Level and Pre-eclampsia Risk in African Women: a Systematic Review and Meta-analysis by Tesfa E, Nibret E and Munshea A.
Link:
https://pubmed.ncbi.nlm.nih.gov/33527339/
Additional information of El Mondo:
Find more information/studies on zinc and food fortification/malnutrition right here.
Pre-eclampsia is a disorder of pregnancy characterized by the onset of high blood pressure and often a significant amount of protein in the urine.