Nutritional Advice El MondoObjectives:
Oxidative stress has been found to be implicated in the development of Alzheimer's disease (AD). Therefore, this review article has been conducted.
Is there an association between selenium level in the brain and Alzheimer’s disease?
Study design:
This review article included 14 studies with 40 observations on selenium concentrations in Alzheimer’s disease and control brains (persons without Alzheimer’s disease).
The effect size as standardized mean difference (SMD) was generated using review manager 5.3.
The funnel plot with Egger's [p = 0.88] and Begg's tests [p = 0.24] detected no significant publication bias.
Results and conclusions:
The investigators found random-effects meta-analysis indicated a decrease [SMD = - 0.42] in brain tissue selenium levels in patients with Alzheimer’s disease as compared to non-Alzheimer’s disease controls.
The results of sensitivity analysis indicated that no single study/observation had significantly influenced the overall outcome.
The investigators found the subgroup meta-analysis demonstrated that the selenium levels were decreased in the temporal, hippocampal and cortex regions of the brains in patients with Alzheimer’s disease.
The results of sensitivity analysis indicated that no single study/observation had significantly influenced the overall outcome.
The investigators concluded there is consolidated evidence for a significant decrease of selenium status in Alzheimer’s disease brains compared to controls (persons without Alzheimer’s disease). In line with the evidence supporting selenium's antioxidant role and the involvement of oxidative stress in Alzheimer’s disease development, these findings support new therapeutic strategies aimed at brain tissue selenium homeostasis in Alzheimer’s disease.
Original title:
Brain Selenium in Alzheimer's Disease (BRAIN SEAD Study): a Systematic Review and Meta-Analysis by Varikasuvu SR, Prasad VS, [...], Manne M.
Link:
https://www.ncbi.nlm.nih.gov/pubmed/30171594
Additional information of El Mondo:
Find more information/studies on selenium and Alzheimer’s disease right here.