Nutritional Advice El Mondo
Objectives:
Are declined circulating vitamin D levels associated with severity of hepatitis C virus (HCV) infection?
Study design:
This review article included 28 studies, consisting of 7,736 HCV-infected patients and 14,061 control subjects without liver diseases.
Results and conclusions:
The investigators found compared to controls, circulating vitamin D levels were significantly lessened in HCV-infected patients [MD = -14.15, 95% CI = -20.51 to -7.80].
The investigators found remarkably decreased circulating vitamin D in patients with severe fibrosis [MD = -3.38, 95% CI = -4.51 to -2.25], non-achieving sustained virologic response (SVR) [MD = -2.99, 95% CI = -5.55 to -0.42] and advanced inflammation [MD = -4.68, 95% CI = -8.50 to -0.86].
The investigators found low vitamin D status (20 ng/mL) significantly increased HCV infection with 141% [pooled OR = 2.41, 95% CI = 1.48 to 3.95].
The investigators found a significantly increased risk of 70% [pooled OR = 1.70, 95% CI = 1.27 to 2.26] for severe fibrosis among HCV-infected patients with low vitamin D status.
The investigators found a significantly increased risk of 104% [pooled OR = 2.04, 95% CI = 1.62 to 2.57] for non-achieving SVR among HCV-infected patients with low vitamin D status.
The investigators concluded hepatitis C virus (HCV)-infected patients with declined circulating vitamin D levels are associated with severe fibrosis, non-achieving sustained virologic response (SVR) and advanced inflammation.
Original title:
Decreased Circulating Vitamin D Reflects Adverse Outcomes of Hepatitis C Virus Infection: A Systematic Review and Meta-Analysis by Udomsinprasert W, Jittikoon J, […], Chaikledkaew U.
Link:
https://pubmed.ncbi.nlm.nih.gov/32553842/
Additional information of El Mondo:
Find more information/studies vitamin D and malnutrition right here.
Virologic response means that the hepatitis C virus is not detected in the blood during treatment. When the hepatitis C virus continues to be undetectable 12 weeks or more after completing treatment, a “sustained” virologic response (SVR) has been achieved.