Male are more susceptible to severe COVID-19 infection than women

Afbeelding

Objectives:
Severe Acute Respiratory Syndrome coronavirus-2 (SARS-CoV) has been recently characterized and soon spread around the world generating a pandemic. It has been suggested that men are more severely affected by the viral disease (COVID-19) than women. Therefore, this review article has been conducted.

What is the influence of gender on COVID-19 mortality, severity and disease outcomes?

Study design:
This review article included 85 articles.

Results and conclusions:   
The investigators found in a random-effect meta-analysis that male to female ratio was 1: 0.8.

The investigators found a significant association between male sex and mortality [OR = 1.81, 95% CI = 1.25 to 2.62], as well as a lower chance of recovery in men [OR = 0.72, 95% CI = 0.55 to 0.95].

The investigators found male patients had a higher odd to present with a severe form of COVID-19 [OR = 1.46, 95% CI = 1.10 to 1.94].

The investigators concluded male are more susceptible to COVID-19 infection, present with a more severe disease and have a worse prognosis. Further studies are warranted to unravel biological mechanisms underlying these observations.

Original title:
Does gender influence clinical expression and disease outcomes in COVID-19? A systematic review and meta-analysis by Ortolan  A, Lorenzin M, […], Ramonda R.

Link:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7422797/

Additional information of El Mondo:
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