Melatonin supplements have positive effects on sleep quality in adults with metabolic disorders

Objectives:
Do melatonin supplements improve sleep quality as assessed by the Pittsburgh Sleep Quality Index (PSQI) in adults with various diseases?

Study design:
This review article included a total of 23 RCTs.

Results and conclusions:
The investigators found that melatonin supplements had significant effects on sleep quality as assessed by the Pittsburgh Sleep Quality Index (PSQI) [WMD = -1.24, 95% CI = -1.77 to -0.71, p = 0.000, I2 = 80.7%, p = 0.000].

The investigators found subgroup analysis based on health status revealed melatonin supplements in subjects with respiratory diseases [WMD = -2.20, 95% CI = -2.97 to -1.44, p = 0.000], metabolic disorders [WMD = -2.74, 95% CI = -3.48 to -2.00, p = 0.000] and sleep disorders [WMD = -0.67, 95% CI = -0.98 to -0.37, p = 0.000] had significant effects on sleep quality.

The investigators concluded the treatment with exogenous melatonin (melatonin supplements) has positive effects on sleep quality as assessed by the Pittsburgh Sleep Quality Index (PSQI) in adults, particularly with respiratory diseases, metabolic disorders, primary sleep disorders; however, not with mental disorders, neurodegenerative diseases and other diseases.

Original title:
Effect of melatonin supplementation on sleep quality: a systematic review and meta-analysis of randomized controlled trials by Fatemeh G, Sajjad M, […], Khadijeh M.

Link:
https://pubmed.ncbi.nlm.nih.gov/33417003/

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