Mortality rate of patients admitted to intensive care unit with COVID-19 is around 41%

Afbeelding

Objectives:
The emergence of coronavirus disease 2019 (COVID-19) has led to high demand for intensive care services worldwide. However, the mortality of patients admitted to the Intensive Care Unit (ICU) with COVID-19 is unclear. Therefore, this review article has been conducted.

What is the mortality rate of patients admitted to the Intensive Care Unit (ICU) with COVID-19?

Study design:
This review article included 24 observational studies, including 10,150 patients from centres across Asia, Europe and North America. In-ICU mortality in reported studies ranged from 0-84.6%.
7 studies reported outcome data for all patients. In the remaining studies, the proportion of patients discharged from ICU at the point of reporting varied from 24.5-97.2%.

Results and conclusions:   
The investigators found in patients with completed ICU admissions with COVID-19 infection, combined ICU mortality was 41.6% [95% CI = 34.0 to 49.7%, I2 = 93.2%].
Subgroup analysis by continent showed that mortality is broadly consistent across the globe.

The investigators found as the pandemic has progressed the reported mortality rates have reduced from above 50% to close to 40%.

The investigators found the in-ICU mortality from COVID-19 was higher than usually seen in ICU admissions with other viral pneumonias.

The investigators found, importantly, the mortality from completed episodes of ICU differed considerably from the crude mortality rates in some early reports.

The investigators concluded in patients with completed ICU admissions with COVID-19 infection, combined ICU mortality is around 41%. This mortality rate is broadly consistent across the globe.

Original title:
Outcomes From Intensive Care in Patients With COVID-19: A Systematic Review and Meta-Analysis of Observational Studies by Armstrong RA, Kane AD and Cook TM.

Link:
https://pubmed.ncbi.nlm.nih.gov/32602561/

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