Nutritional Advice El Mondo
Objectives:
Cholera has harmful effects on the foetus but safety data of the oral cholera vaccine in pregnant women is controversial. Therefore, this review article has been conducted.
Has cholera vaccination during pregnancy harmful effects on the foetus?
Study design:
This review article included 5 studies with 5,584 pregnant women (2,920 exposed and 2,664 not exposed).
Results and conclusions:
The investigators found no significant increase in adverse pregnancy outcome [RR = 1.03, 95% CI = 0.79 to 1.34] or miscarriage [RR = 1.15, 95% CI = 0.84 to 1.57] or stillbirth [RR = 1.11, 95% CI = 0.69 to 1.80] following cholera vaccine administration during pregnancy compared to control group (group without cholera vaccine administration).
Significant because RR of 1 was found in the 95% CI of 0.69 to 1.80. RR of 1 means no risk/association.
The investigators found no association with an increased risk of preterm delivery [RR = 0.61, 95% CI = 0.35 to 1.06], low birth weight [RR = 0.84, 95% CI = 0.56 to 1.26], accidental abortion [RR = 1.02, 95% CI = 0.77 to 1.35] and malformation [RR = 0.70, 95% CI = 0.22 to 2.25] following cholera vaccine administration during pregnancy compared to control group.
The investigators concluded there is no evidence of an association among oral cholera vaccination and adverse pregnancy outcomes. However, these findings do not rigorously exclude the possibility that the vaccine protocol may result in some degree of harm.
Original title:
Pregnancy Outcomes after a Mass Vaccination Campaign with an Oral Cholera Vaccine: A systematic review and meta-analysis by Zhang Y, Zhang H, [...], Li Z.
Link:
https://www.ncbi.nlm.nih.gov/pubmed/32289871
Additional information of El Mondo:
Find more information/studies on vaccination, pregnancy and food fortification right here.